脑部疾病精准靶向治疗具有广阔的应用前景，尤其是采用具有多功能、靶向性、智能化的纳米粒子作为药物载体，能够实现脑胶质瘤、阿尔茨海默症等脑部相关疾病的高效治疗。相比于传统药物使用方式，采用智能纳米递送系统进行药物递送，能够大幅度提高药物利用度、改变药物组织器官分布、提高药物生物安全性。对于递送药物种类的选择，除了传统的化学类药物，还包括核酸及蛋白类药物。本中心利用无机、有机或者仿生纳米材料，通过构建具有脑靶向性、智能性的纳米药物载体，探索多种治疗模式（光热治疗、化疗、基因药物治疗，蛋白药物治疗等），从而实现对于脑部相关疾病的高效治疗。该方向的研究内容包括如下几个方面：

（1）智能纳米药物递送系统的设计与构建；

（2）核酸、化疗、蛋白药物精准递送；

（3）脑部疾病靶向治疗及安全性评估。

代表性论文：

1. Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment. Y. Zou, X. Sun, Y. Wang, C. Yan, Y. Liu, J. Li, D. Zhang, M. Zheng*, R. S. Chung and B. Shi*.  Advanced Materials. 2020, 2000416 (IF=25.809)

2. Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy. Y. Liu,# Y. Zou,# C. Feng,# A. Lee, J. Yin, R. Chung, J. B. Park, H. Rizos, W. Tao, M. Zheng,* O. C. Farokhzad,* B. Shi*.  Nano Letters. 2020, 20, 1637–1646. (IF=12.279)

3. ROS Responsive Polymeric siRNA Nanomedicine Stabilized by Triple-Interactions for the Robust  Glioblastoma Combinational RNAi Therapy. M. Zheng,# Y. Liu,# Y. Wang, D. Zhang, Y. Zou, W. Ruan, J. Yin, W. Tao, J. B. Park, and B. Shi*. Advanced Materials. 2019, 1903277.(IF=25.809)

4. The siRNAsome: A Cation Free and Versatile Nanostructure for siRNA and Drug Codelivery. M. Zheng,# T. Jiang,# W. Yang, Y. Zou, H. Wu, X. Liu, K. McDonald, D. Ling, J. Shi, F. Zhu, R. Qian and B. Shi*. Angewandte Chemie International Edition. 2019, 58, 4938–4942. (IF=12.257)

5. Effective and Targeted Human Orthotopic Glioblastoma Xenografts Therapy via a Multifunctional Biomimetic Nanomedicine. Y. Zou#, Y. Liu#, Z. Yang, D. Zhang, Y. Lu, M. Zheng*, X. Xue, J. Geng, R. Chung, B. Shi*. Advanced Materials. 2018; 30: 1803717. (IF=25.809)