多形性胶质母细胞瘤(Glioblastoma multiforme，GBM)是胶质瘤的一种，是恶性程度及致死率最高的脑部肿瘤。GBM肿瘤细胞具有高浸润性、可大范围转移，不可避免的导致肿瘤复发。而少数具有干细胞特性的胶质瘤干细胞 (GBM stem cells, GSCs)是GBM肿瘤形成、发展、浸润侵袭、复发和导致放化疗抗性的根本原因。因此，筛选和鉴定调节胶质瘤干细胞的特异性信号通路及关键基因将为开发针对GBM的有效疗法提供重要线索和依据。该方向的研究内容包括如下几个方面：

1） 胶质瘤干细胞特性维持及信号调节机制研究；

2） 胶质瘤干细胞肿瘤微环境的形成及相互作用机制研究；

3） 胶质瘤干细胞的靶向治疗研究；

4） 患者胶质瘤干细胞的分离、培养，PDX模型的构建及个体化治疗研究。

代表性论文：

1. ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages. Yin J*#, Kim SS#, Choi E#, Oh YT#, Lin W, Kime TH, Sa JK, Hong JH, Park SH, Kwon HJ, Jin X, You Y, Kim JH, Kim H, Son J, Lee J, Nam DH, Choi KS, Shi B, Gwak HS, Yoo H, Iavarone A*, Kim JH*, Park JB*. Nature Communications. 2020, 11: 2978 [IF=12.121].

2. Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBPβ Signaling. Yin J#, Oh YT#, Kim JY#, Kim SS#, Choi E, Kim TH, Hong JH, Chang N, Cho HJ, Sa JK, Kim JC, Kwon HJ, Park S, Lin W, Nakano I, Gwak HS, Yoo H, Lee SH, Lee J, Kim JH, Kim SY, Nam DH*, Park MJ*, Park JB*. Cancer Research. 2017, 77: 4973-4984 [IF: 9.727].

3. DEAD-box RNA helicase DDX23 modulates glioma malignancy via elevating miR-21 biogenesis. Yin J#, Park G#, Lee JE#, Choi EY#, Park JY, Kim TH, Park N, Jin X, Jung JE, Shin D, Hong JH, Kim H, Yoo H, Lee SH, Kim YJ*, Park JB*, Kim JH*. Brain. 2015, 138: 2553-70 [IF: 11.337].

4. Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells. Yin J#, Park G#, Kim TH, Hong JH, Kim YJ, Jin X, Kang S, Jung JE, Kim JY, Yun H, Lee JE, Kim M, Chung J, Kim H, Nakano I, Gwak HS, Yoo H, Yoo BC, Kim JH, Hur EM, Lee J, Lee SH, Park MJ*, Park JB*. PLoS Biololgy. 2015, 13: e1002152 [IF: 7.076].