河南省脑靶向生物纳米药物重点实验室
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DNA nanoclew templated spherical nucleic acid for siRNA delivery. 

Weimin Ruan, Meng Zheng,* Yang An, Yuanyuan Liu, David B. Lovejoy, Mingcong Hao, Yan Zou, Albert Lee, Shu Yang, Yiqing Lu, Marco Morsch, Roger Chung and Bingyang Shi*

Chemical Communications. 2018; 54: 3609-3612.(IF=6.065)

Abstract

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed a DNA nanoclew (DC). After uptake by cultured cancer cells, SNA nanoparticles release engrafted siRNAs by cleavage of the intracellular Dicer enzyme. Moreover, in vitro experiments reveal that such SNAs demonstrate potent gene knockdown at both mRNA and protein levels, while with negligible cytotoxicity.





  地址
河南省开封市
河南大学金明校区,生命科学学院
475004
 技术支持:河南科加
  联系方式
邮箱: jcbi@vip.henu.edu.cn
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