王杰菲，副教授，硕士生导师。

E-mail：jfwang@henu.edu.cn

研究领域：纳米诊疗剂的构建及脑疾病精准诊疗研究。

入选河南省中原青年拔尖人才、河南省优青、河南省高校科技创新人才、国家博士后创新人才。2017年入职河南大学—麦考瑞大学生物医学联合创新中心。主持国家自然科学面上基金、国家自然科学青年基金、中国博士后创新人才计划、河南省优秀青年基金、河南省科技研发联合培育基金、河南省高校科技创新人才支持计划、中国博士后科学基金面上项目（一等）等13项国家/省部级项目。在Science Translational Medicine、Science Advances、Nature Communications、Advanced Materials、Angew. Chem. Int. Ed., Advanced Science、ACS Nano、Nano Letters等国际主流期刊上发表SCI论文近40篇（17篇一作/通讯IF > 10），授权中国发明专利13项。获得河南省自然科学奖二等奖、河南省科技成果奖一等奖、河南省教育厅优秀科技论文奖一等奖、河南省优秀创新创业教师等奖项。

承担项目：

1. 国家自然科学基金面上项目，铋烯原位诱导AIE限域聚集及其脑胶质瘤NIR-Ⅱ手术导航与术后增强PDT诊疗研究，202301-202612。

2. 国家自然科学基金青年项目，脑靶向双光子AIE近红外诊疗探针的构建及其AD诊疗一体化应用研究，202101-202312。

3. 国家博士后创新人才支持计划，新型金属卟啉碳点的构筑及其用于脑部肿瘤的NIR光热/成像研究，201901-202012。

4. 中原青年拔尖人才，202602-202902。

5. 河南省优秀青年科学基金项目，双靶点诊疗型NIR探针的构建及其AD治疗机制研究，202401-202612。

6. 河南省高校科技创新人才支持计划，脑靶向近红外AIE纳米诊疗剂的构建及脑胶质瘤诊疗研究，202201-202412。

7. 河南省科技研发计划联合基金培育项目，近红外纳米酶设计用于食管鳞癌可视化诊疗研究，202301-202412。

8. 河南大学“青年英才”，202110-202410。

9. 中国博士后科学基金面上项目（一等），共组装制备增强光吸收卟啉纳米复合物用于MRI/PDT应用，201901-202012。

10. 河南省自然科学基金青年科学基金项目，双刺激响应的金卟啉自递送系统的自组装构建及协同治疗研究，202001-202112。

代表性论文：

1. Ping Shangguan, Yong Zhong, Haigang Wu, Yisheng Liu, Gaoyang Wang, Cai Qi, Jiang Ouyang, Senfeng Zhao, Xin Wang, Jinlong Yin, Xiaoyuan Ji, Feng Bai, Kelong Fan, Jiefei Wang*, Wei Tao*, Bingyang Shi*. Spatiotemporal-switchable 2D NIR-II single-atom nanozyme for single-cell level surgical navigation and glioblastoma phototherapy. Sci. Transl. Med. 2026, eaeb8054.

2. Yisheng Liu, Xiang Su, Yong Zhong, Ping Shangguan, Jun Zhu, Zhengqun Luo, Haigang Wu, Dong Wang, Ting Han, Jiefei Wang*, Bingyang Shi*, Ben Zhong Tang*. Two-dimensional NIR-II AIE nanotheranostic probes with ultralarge Stokes shifts for surgical navigation and ablation of glioma. Sci. Adv. 2026, 12, eaeb 5389.

3. Jiefei Wang, Ping Shangguan, Xiaoyu Chen, Yong Zhong, Ming Lin, Mu He, Yisheng Liu, Yuan Zhou, Xiaobin Pang, Lulu Han, Mengya Lu, Xiao Wang, Yang Liu, Huiqing Yang, Jingyun Chen, Chenhui Song, Jing Zhang, Xin Wang, Bingyang Shi. Ben Zhong Tang. A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease. Nat. Commun. 2024, 15, 705-720.

4. Jiefei Wang, Mingyue Cao, Lulu Han, Ping Shangguan, Yisheng Liu, Yong Zhong, Chaoyue Chen, Gaoyang Wang, Xiaoyu Chen, Ming Lin, Mengya Lu, Zhengqun Luo, Mu He, Herman H. Y. Sung, Guangle Niu, Jacky W. Y. Lam, Bingyang Shi, Ben Zhong Tang. Blood–Brain Barrier-Penetrative Fluorescent Anticancer Agents Triggering Paraptosis and Ferroptosis for Glioblastoma Therapy. J. Am. Chem. Soc. 2024, 146, 42, 28783–28794.

5. Brain-Targeted Near-Infrared Chiral TeSe Nanodrug Against Orthotopic Drug-Resistant Glioma.  Yisheng Liu, XiLi, Qingxiang Zhu, Yong Zhong, Xuhong Lin, Chaoqun Zhou, Cai Qi, Jincheng Guo, Qinqin Ma, Haigang Wu, Gaoyang Wang*, Feng Bai*, Jiefei Wang*. Angew. Chem. Int. Ed. 2026, 65(3), e202516990.

6. Tianfu Zhang, Xiaoyu Chen, Congmin Yuan, Xiaobin Pang, Ping Shangguan, Yisheng Liu, Lulu Han, Jianwei Sun, Jacky W. Y. Lam, Yang Liu, Jiefei Wang*, Bingyang Shi*, Ben Zhong Tang*. Near-Infrared Aggregation-Induced Emission Luminogens for In Vivo Theranostics of Alzheimer’s Disease. Angew. Chem. Int. Ed. 2023, 62(2), e202211550 (高被引).

7. Jiefei Wang, Yisheng Liu, Marco Morsch, Yiqing Lu, Ping Shangguan, Lulu Han, Zhongjie Wang, Xiaoyu Chen, Chenhui Song, Shunjie Liu, Bingyang Shi, Ben Zhong Tang. Brain-Targeted Aggregation-Induced-Emission Nanoparticles with Near-Infrared Imaging at 1550 nm Boosts Orthotopic Glioblastoma Theranostics. Adv. Mater. 2022, 34, 2106082.

8. Nizi Song, Mengya Lu, Jiancai Liu, Ming Lin, Ping Shangguan, Jiefei Wang,* Bingyang Shi,* Junwei Zhao*. A Giant Heterometallic Polyoxometalate Nanocluster for Enhanced Brain-Targeted Glioma Therapy. Angew. Chem. Int. Ed. 2024, 63(10), e202319700 (封面文章).

9. Jiefei Wang, Ping Shangguan, Ming Lin, Libing Fu, Yisheng Liu, Lulu Han, Sudi Chen, Xiao Wang, Mengya Lu, Zhengqun Luo, Yong Zhong, Bingyang Shi, Feng Bai. Dual-Site Förster Resonance Energy Transfer Route of Upconversion Nanoparticles-Based Brain-Targeted Nanotheranostic Boosts the Near-Infrared Phototherapy of Glioma. ACS Nano 2023, 17, 17, 16840–16853.

10. Jing Zhang, Lulu Han, Haigang Wu, Yong Zhong, Ping Shangguan, Yisheng Liu, Mu He, Han Sun, Chenhui Song, Xin Wang, Yang Liu, Jiefei Wang*, Lei Zheng*, Bingyang Shi*, Ben Zhong Tang*. A Brain-Targeting NIR-II Ferroptosis System: Effective Visualization and Oncotherapy for Orthotopic Glioblastoma, Adv. Sci. 2023,10(13), 2206333 (封面文章).

11. Engineering near-infrared organic small molecules for photodynamic therapy. Xiaoyan Yang, Yangwei Jiang, Jianlei Qian, Chu Hao, Yong Zhong, Jiayin Wang, Jiefei Wang*, Feng Bai*. Coord. Chem. Rev. 2026, 549, 217372.

12. Jiefei Wang, Yisheng Liu, Cai Qi, Zhengqun Luo, Jinfeng Wei, Gaoyang Wang, Muhammad Ismail, Yong Zhong, Bingyang Shi. Near-infrared theranostics for brain diseases: Design, engineering, and emerging applications. Coord. Chem. Rev. 2025, 534, 216591.

13. Xiang Su, Yisheng Liu, Yong Zhong, Ping Shangguan, Junkai Liu, Zhengqun Luo, Cai Qi, Jincheng Guo, Xi Li, Danmin Lin, Gaoyang Wang, Dong Wang, Ting Han, Jiefei Wang*, Bingyang Shi*, Ben Zhong Tang*. A Brain-Targeting NIR-II Polymeric Phototheranostic Nanoplatform toward Orthotopic Drug-Resistant Glioblastoma. Nano Lett. 2025, 25, 3445−3454.

14. Jiefei Wang, Zhongjie Wang, Yong Zhong, Yan Zou, Chong Wang, Haigang Wu, Albert Lee, Weitao Yang, Xiao Wang, Yanjie Liu, Dongya Zhang, Jiliang Yan, Mingcong Hao, Meng Zheng, Roger Chung, FengBai, Bingyang Shi. Central Metal-Derived Co-Assembly of Biomimetic GdTPP/ZnTPP Porphyrin Nanocomposites for Enhanced Dual-Modal Imaging-Guided Photodynamic Therapy. Biomaterials 2020, 229, 119576.

15. Jiefei Wang, Yong Zhong, Xiao Wang, Weitao Yang, Feng Bai, Bingbo Zhang, Leanne Alarid, Kaifu Bian, Hongyou Fan. pH-Dependent Assembly of Porphyrin-Silica Nanocomposites and their Application in Targeted Photodynamic Therapy, Nano Lett. 2017, 17(11), 6916-6921.

16. Jiefei Wang, Yong Zhong, Liang Wang, Na Zhang, Ronghui Cao, Kaifu Bian, Leanne Alarid, Raid E. Haddad, Feng Bai, Hongyou Fan. Morphology-Controlled Synthesis and Metalation of Porphyrin Nanoparticles with Enhanced Photocatalytic Performance, Nano Lett. 2016, 16, 6523-6528.

17. Xiao Wang#, Jiefei Wang#, Jinghan Wang, Yong Zhong, Lulu Han, Jiliang Yan, Pengcheng Duan, Bingyang Shi, Feng Bai*. Noncovalent Self-Assembled Smart Gold(Ⅲ) Porphyrin Nanodrug for Synergistic Chemo-Photothermal Therapy. Nano Lett. 2021, 21, 3418-3425.

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